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To assess the significance of the findings replication in other cohorts is needed.
Given these limitations as well as the unexpected findings, replication of these results in another US-based cohort is particularly important.
As the authors correctly point out, before generalizing these findings, replication with other populations is necessary [ 5].
Though our equi-percentile scores were highly comparable to those recently reported, which adds to some confidence to our findings, replication in community populations would strengthen our recommendations.
Consistent with these findings, replication origins in these minireplicons are variable, which indicates that the frequent evolution of extrachromosomal elements might be associated with origin variation.
The use of three franchise systems in three different healthcare sectors enabled us to confirm our findings (replication) and to identify diverging patterns across settings, thereby reaching more explanatory power and generalizability [ 41, 43, 44].
Similar(54)
Other options in the HTML output include viewing alignment, viewing Position Specific Probability Matrix (PSPM), and finding replications that are similar to the best motif found [ 5].
For modeling the Proteus phenomenon, we assigned one of three categories to each case-control study: initial findings, early replications, and late replications.
Findings await replication and more careful testing within a randomized controlled trial.
However, many of the findings await replication in other samples and populations.
The number of participants was substantial but these findings require replication.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com