This finding is underscored by the complete absence of Txnrd1 protein observed in brain homogenates from Txnrd1-NS null mice.
The structural and functional significance of this finding is underscored by a similar dependence on OGT of disorder found in long IDRs and mostly disordered proteins (Supplementary material, Figure S2).
The importance of this finding is underscored by earlier research demonstrating that QOL scores are themselves independent predictors of patient mortality.
This finding is underscored by the fact that phosphorylation of STAT3 is associated with markers of stability in human carotid atherosclerotic plaques.
The importance of this finding is underscored by our knowledge that insulin resistance is a very prominent and early feature of the metabolic syndrome and has consistently been associated with fetal programming in humans, regardless of whether the exposure is low birthweight, prematurity independent of low birthweight, gestational diabetes mellitus (GDM) or twin/zygosity status [ 9– 11].
This finding is underscored by our analysis of the AIL mouse data set, where five loci reach genome-wide significance when this approach is used, whereas only one locus meets genome-wide significance when all markers are used to estimate the matrices.
We also show here that (v) excitatory CA VII-dependent GABA signalling promotes eFS at P14, and the relevance of this finding is underscored by the observation (vi) that CA VII is expressed in the human cortex perinatally, well in advance of the age of 6 months when FS are first seen in children (Berg and Shinnar, 1996; Stafstrom, 2002).
The clinical significance of these findings was underscored by two independent groups showing that high expression of IGFBP-3 in breast tumor tissue is associated with markers of aggressiveness and poor prognosis, including ER- and progesterone receptor- (PR-) negativity, high S-phase fraction, and aneuploidy [ 32, 33].
The functional significance of these findings is underscored by the identification of a strong positive correlation between liver docosahexaenoic acid content and cognitive status (P<0.0001).
The significance of our findings is underscored by the fact that both Chk1 and Wee1 are important pharmacological targets.
