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A dose finding study was performed to find a dose of death camas that caused minimal clinical signs of poisoning.
The study was designed as a dose finding study of paclitaxel in chemotherapy-naive patients.
First, a dose finding study was undertaken in mice infected with H37Rv.
A dose finding study of doxil-carboplatin-paclitaxel was therefore undertaken in women receiving first-line therapy.
Overall, the manageable tolerability profile and the encouraging activity in this dose finding study support further clinical development of this combination for treatment of solid tumours.
No major toxicities had been observed at this dose level in a separate non-GLP multiple dose-range finding study in cynomolgus monkeys (data not shown).
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"This is a context-finding study rather than a causal study, so we're not saying 'you play violent videogames, you get more aggressive,'" says Etchells.
A dose-finding study was performed as the first step in the clinical development of the new drug, cizolirtine citrate.
Data were obtained from a Phase-II dose-finding study of orbofiban in patients presenting with acute coronary syndromes.
Although this was not a dose-finding study, it might be expected that a dose of 8 MBq is high enough for SLN detection.
The intravenous RCT was a randomised, multicentre, double-blind, placebo-controlled, group-sequential, adaptive treatment-assignment, proof-of-concept and dose-finding study [15].
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