Notably, correcting for tumour size did not change the finding that spindle cell morphology patients have a significantly worse prognosis.
Given our finding that spindle cell morphology does not affect the risk of local recurrent disease, the current advice to perform a local radical tumour resection with 8-mm tumour-free margins after fixation seems appropriate (de Hullu and van der Zee, 2006).
Importantly, we found no significant associations between CA and spindle MP, which corroborates our finding that declustering drugs appear to induce spindle MP by disrupting spindle pole and/or centrosome integrity, which in some cases may also decluster centrosomes if an excess is present.
We confirmed this assumption by finding that 5/5 FM232 (GFP PH) spindles longer than 4 μm exhibited deep cortical furrows.
We applied statistical modeling, based on data integration, for finding yeast genes involved in spindle migration from two synthetic lethality screens performed with arp1 and jnm1.
The current study was motivated by our finding that signals recorded during spindles simultaneously by EEG and MEG sensors have strikingly different characteristics [23].
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a Histopathological findings revealed spindle-shaped cells (hematoxylin and eosin stain, ×200).
This concept was further underscored by the findings that spindles assembled in Xenopus egg extracts are extensively decorated by ribosomes [26].
Although we cannot conclusively distinguish between these two possibilities at present, our findings that spindles reposition basally in LatB treatment, MHC-B morphants, and with expression of full-length Myo10 and the microtubule-binding IQT-Myo10 strongly suggest that the microtubule network does exert a basally directed force, in addition to any barrier function.
