According to this study's findings, clinical severity of psoriasis measured by PASI seems to be an independent variable in the relationship between EDs, MBS, and anxiety.
Our finding of an association between psoriasis and dialysis dependent end stage renal disease further argues that the association between psoriasis and chronic kidney disease is not driven solely by the overdiagnosis of subclinical renal impairment.
Our previous finding on the genetic association of psoriasis with the defensin cluster did not allow discrimination between the seven defensins or defensin-like genes contained in the repeated segment.
These findings underscore the polygenic basis of psoriasis and suggest that pathogenesis involves numerous biochemical pathways.
Our findings indicate that approximately 50% of psoriasis DEGs can be attributed to resident skin cells, although the dominant cell type differs between psoriasis-increased DEGs (keratinocytes, 35%) and psoriasis-decreased DEGs (fibroblasts, 33%).
One of the possible explanations for differences in the findings could be more severe degree of psoriasis among participants investigated in the present study.
Its involvement in the pathogenesis of psoriasis is suggested by the finding that uninvolved psoriatic skin develops psoriasis-like lesions at the site of IFN-gamma injection [ 15].
These findings offer new insights into the underlying transcriptional circuitry of psoriasis lesions, and demonstrate how sequence-specific TF/uDBP-DNA interactions can be exploited to support dODN drug development and enhance interpretation of non-coding GWAS signals.
The present study assessed periodontal conditions in individuals with moderate and severe psoriasis with long disease exposure time (mean 22 years), but, it remains uncertain whether our findings can be generalized to individuals with milder forms of psoriasis.
The main findings of the first psoriasis GWAS, involving 1,446 US patients and 1,432 controls, reported association with four variants mapping to two non-MHC genes from the genotyping of 25,215 gene-centric SNPs: IL12B on chromosome 5q and IL23R, a gene encoding an interleukin receptor, on chromosome 1p of the broad PSORS7 locus, identified in early studies [ 30, 50].
