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This analysis confirmed the finding of abnormalities present in the right hemisphere, with the location of the clusters the same as the original observation but slightly increased in size, likely because of the reduced number of multiple comparisons.
The finding of abnormalities unrelated to clinical phenotypes illustrates that important pathology phenotypes will be missed if histopathology is restricted to perceived target organs or tissues based on clinical phenotyping.
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The living human brain is not readily accessible to direct investigation, and the dead brain undergoes chemical change; moreover, findings of abnormalities in cerebrospinal fluid, blood, or urine may have no relevance to the question of a presumed biochemical imbalance in the brain.
Certain findings of abnormalities in the T sperm group were further examined under eosin/nigrosin staining or using scanning electron microscopy.
Depending on targeted or non-targeted analysis and on the level of resolution, NIPT for common autosomal aneuploidies may lead to findings of abnormalities in other chromosomes, including submicroscopic abnormalities.
In the absence of anaemia, which is the marker of severe iron deficiency, our findings of abnormalities in several of these indicators (as used in our definition of iron deficiency) implies the presence of a moderate rather than a mild iron deficiency.
Depending on the abnormality, the finding of cytogenetic abnormalities on conventional metaphase cytogenetics may also indicate the development of secondary myelodysplastic syndrome.
In conclusion, we consider that the finding of diffusion abnormalities in the cerebral white matter of PDD patients reflects structural changes resulting from Lewy abnormalities in the cerebral white matter.
Given the recent emphasis on mitotic spindle orientation in cortical neurogenesis and our previous finding of mitotic abnormalities in ATRX-depleted human cells (Ritchie et al., 2008), we investigated whether mouse Atrx-null NPCs exhibit similar mitotic defects.
The finding of mitochondrial abnormalities in the biopsies of few of the ALS patients in this cohort and other published studies suggest some link whether primary or secondary to the pathogenesis of ALS or the ultimate motor neuron injury [ 44, 48].
A number of previous studies have examined the relationship of clinical findings to abnormalities of nerve conduction [ 6, 9- 30], but most have been small [ 10- 15, 15- 18, 20- 24, 24- 28] or have assessed associations with pre-defined composite scores without attempting to disentangle the relative importance of different component symptoms and signs [ 10, 20- 29, 29].
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