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A SOFA score (Sequential Organ Failure Assessment) [ 16] was calculated on 1 3 days after positive blood culture finding (data available from 135/149 patients).
Including deaths with diabetes as the underlying cause in the definition of CVD deaths did not change this finding (data available on request).
Similar(58)
Multiple imputations of these variables using Chained Equations imputation (20 imputations) yielded very similar findings (data available upon request).
An additional region of interest analysis, not reported here, based on coordinates reported in Smith et al. (2004) for the same contrast revealed almost complete overlap with their findings (data available upon request).
The women who were excluded based on missing data were more likely to be from ethnic minorities and to be smokers, but their general characteristics were very similar to those of the population investigated; thus, it is unlikely that this exclusion had a large effect on our findings (supplemental data, available at http://care.diabetesjournals.org/cgi/content/full/dc09-1088/DC1).
We investigated the distribution in saliva and blood of the eight mosaic copy number events with validation data available, finding that two were present in both saliva and blood, six were present in saliva but not blood and no events were present in blood alone.
But the reality is that it is nearly impossible to come to conclusive findings given the data available.
Representativeness of the sample studied in this survey may be assessed by comparison of its findings with national data available from other sources.
Findings: Data were available for more than 550 000 individuals and 51 623 cases of type 2 diabetes.
To confirm this finding we surveyed the data available at the Broad-Novartis Cancer Cell Line Encyclopedia (CCLE, http://www.broadinstitute.org/ccle/home) and found that the log2 mRNA levels of TrkA are indeed quite low (median log2 = 3.8; CI: 3.8 4.0), although a fraction of these cells lines show gain or amplification of the TrkA locus (Additional file 1: Table S5).
These findings are consistent with data available from Mediterranean deep waters [104].
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