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However, we show that this finding cannot be extrapolated to humans as both intradermal and subcutaneous depots of 18F-FDG cause significant and immediate activity accumulation in local venous blood.
Hence, if the toxicity of a given mixture can be well predicted for one endpoint by CA, this finding cannot be extrapolated to other endpoints, with the exception of acute toxicity in Daphnia and fish.
A recent multicentre trial demonstrated reduced duration of antibiotic therapy by using PCT-guided treatment strategy; however, only 10% of the cohort was surgical patients and therefore this finding cannot be extrapolated to a general critical care population [ 3].
Therefore, our finding cannot be extrapolated to the general population of children with CHD but will no doubt benefit from further investigations by other researchers in a more representative and heterogeneous population of children with symptomatic CHD.
One important caveat to this work is that whilst it has demonstrated the apparent success of BCAM compared to other cancer awareness initiatives in raising levels of related online activity, this finding cannot be extrapolated to conclude that this increased activity correlates necessarily with either increased cancer awareness or health seeking activity offline.
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Third, we evaluated only patients admitted to the ICU and, therefore, our findings cannot be extrapolated to patients treated in wards and in the emergency room.
All the non-unions identified for this study were diaphyseal fractures and the findings cannot be extrapolated to other regions of the tibia.
Although our findings cannot be extrapolated to tissue from the vascular zone of the meniscus, our use of avascular tissue prevented possible blood contamination, which would have made accurate comparison difficult.
The present findings cannot be extrapolated the broad Autism spectrum, and further work is needed to explore amygdala function across a range of intellectual abilities.
Finally, participants in this study were adult, had a Karnofsky Score of ≥40; thus our findings cannot be extrapolated to hospitalized patients or children.
Furthermore, our findings cannot be extrapolated to racial groups other than those represented in INFORM (Caucasians and African Americans) and should, therefore, be examined independently in other racial groups.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com