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Meanwhile, research into the health consequences of mercury "has been finding adverse effects at lower and lower exposures," Philippe Grandjean, chair of environmental medicine at the University of Southern Denmark, said in an e-mail.
Therefore any associated bias in the estimated coefficients θ k in Equation 1 would be in the direction of finding adverse short-term employment effects of reform.
A higher threshold would mean more efficiency in finding adverse events.
These results show that although record reviewing has been proved very advantageous in finding adverse events, there is an important disadvantage: record reviewing is very time-consuming.
However, the effect of nicotine on bone remains controversial, with some studies finding adverse effects[ 14, 15] and others showing no effects[ 16, 17].
Looking for more efficient ways to organise patient record reviewing, we investigated how to increase the chance of finding adverse events.
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At the EMA a large database of reports of potential adverse drug reactions, EudraVigilance, is the primary tool for finding new adverse drug reactions.
There have been more than a hundred of these smaller scale studies, many finding one adverse effect or another.
Nevertheless, commonalities among studies finding no adverse effects raise several concerns.
The primary safety variables were unexpected ocular or systemic findings, adverse event rate, and temporary and permanent discontinuation.
Incidence of unexpected ocular or systemic findings, adverse events, and temporary/permanent discontinuation were tabulated and evaluated using Fisher's exact test.
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