Exact(5)
While we find no significant changes in both mutational and neoantigen loads over time between responders and non-responders, we identify B2M aberrations in 29.4% of patients with progressing disease, including multiple early frameshift mutations, LOH overlapping B2M, and absence of tumor-specific B2M protein expression.
We find no significant changes in time allocation for that group.
However, we find no significant changes in the phosphorylation of PRAS40 in response to this hypertrophy stimulus, suggesting that this negative feedback mechanism is not engaged in this scenario.
While the presence of bound MLL significantly increases the order parameters of amino acid residues that are part of the hydrophobic MLL binding pocket (loop L12) and the helices α1 and α2 of the three-helix scaffold of the protein as well as the C-terminal end of helix α3, we find no significant changes of order parameters at the pKID binding site.
Additionally, other energy stress sensors that can feed into mTORC1 such as REDD1 may also play a role in the context of overload-induced hypertrophy; however, we find no significant changes in REDD1 levels in response to overload hypertrophy (data not shown), suggesting that this is unlikely to be regulating growth in this context.
Similar(54)
"We find no significant change whatsoever from last year," he said.
When the equipment was not operating, the researchers found no significant changes in the office air.
Moreover, we found no significant changes in (G) Smad6 protein in any of the group studied.
We found no significant changes in either seedling richness and diversity or in the seedling composition of plant functional groups in response to mammal exclosure.
The saturation of the cell density as well as the maximum proliferation rate decreased, although we found no significant changes on the half maximal time for proliferation.
We found no significant changes in labial saliva flow rates in these bone marrow transplant recipients.
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