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In the post-operative setting, other studies did not find deleterious effects of HES, even in patients with chronic renal dysfunction [ 16, 17].
While some of the informed consent issues for MPS are independent of the study design, others should be adapted based on whether the research study is employing MPS to test a hypothesis (i.e., find the cause of a rare condition in an affected cohort), or to generate hypotheses (i.e., find deleterious or potentially deleterious variants that warrant participant follow-up and further investigation).
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In Ghana, Mazzucato and Cebotari (2017) found deleterious psychological health among children whose parents migrated and were divorced but not when parents migrated and were together.
Previous studies have found deleterious health effects from spending day after day staring at cubicle walls underneath fluorescent light.
Mutations in both donor and recipient were found deleterious, suggesting a role of epithelial and circulating cells in disease mechanisms.
As expected, we also found deleterious effects of genetic similarity and homozygosity of offspring.
Variants found deleterious by any two out of three tools were prioritized.
Though predicted by SIFT as tolerated we also selected rs151296858, rs138685180, and rs147890567 for further analysis as found deleterious by at least 6 SNP analyzers.
Moreover, most of the human studies suggesting an effect of phthalates on reproductive health have focused on males and have found deleterious effects on testicular function and spermatogenesis (Hauser and Calafat 2005).
While some recent studies found deleterious effects in animals with DSS colitis associated with inhibition of COX [ 10– 13], others demonstrated a benefit of COX-2 inhibitor treatment [ 14, 15].
Resequencing germline DNA from 192 familial PrCa cases did not find any deleterious mutations in the coding region of MSMB, hence it is unlikely that this gene is altered by rare deleterious coding mutations in familial PrCa.
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