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To finalize this brief topic of ion-substituted CaPO4, it is important to note that chemical elements not found in natural bones can be intentionally incorporated into CaPO4 biomaterials to get special properties.
To finalize with the collaborations in this topic, Y. Flores-García et al. " CD4+ CD25+ FOXP3+ Treg cells induced by rSSP4 derived from T. cruzi amastigotes increase parasitemia in an experimental chagas disease model" discuss the role in Treg cells induced by rSSP4 derived from T. cruzi amastigotes have in increasing parasitemia in an experimental Chagas' disease model.
9. See the ICH guidance for industry E9 Statistical Principles for Clinical Trials This draft guidance, when finalized, will represent the Food and Drug Administration's (FDA's) current thinking on this topic.
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