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As the reference language for questionnaire development was English, questionnaire finalisation analysis (i.e. item reduction and scale definition) was therefore performed in the "UK finalisation population" set constituted of two-thirds of the UK clinical trial subjects.
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RK contributed to the manuscript design, data analysis and finalisation.
This 0.5 mm cut-off was selected before unblinding, based on the available literature at the time of finalisation of the statistical analysis plan, including a recent consensus recommending defining the cut-off based on the smallest detectable difference in JSN assessment of the reader.
The availability of bioinformatic tools enabling comparative analysis and the finalisation of the human genome prompted us to re-examine the genomic structure of the ghrelin locus.
These additional analyses for response and sustained response were defined in the statistical analysis plan after finalisation of the study protocol but prior to unblinding of the data.
Following finalisation of case studies and further analysis, the practical outcomes of HarmoniCOP (Harmonizing Collaborative Planning) will be developed into a handbook, which will feed into design of guidelines for implementation of the Water Framework Directive.
The study protocol and registration details were updated twice before the finalisation of data entry and subsequent analysis of results to add the terms "iv" and "iv drug" for clarification and because it became apparent that components of the combined primary outcome variable, as initially defined, had different denominators and could not be added to each other.
Finalisation of the data collection procedures and analysis plans will be complete by the end of 2010.
PDM was involved in the design of the study, thematic analysis of all interviews, editing and finalisation of the manuscript for submission.
A detailed analysis plan will be developed prior to finalisation of the dataset.
AJCF and SLRM drafted the statistical analysis plan and LK assisted SLRM with the finalisation.
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CEO of Professional Science Editing for Scientists @ prosciediting.com