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The authors of two of the 116 trial reports had carried out a systematic review and presented the findings within the final trial publication.
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4 Furthermore, major discrepancies in the primary outcomes designated in protocols/registries/regulatory submissions versus final trial publications are common; favour the reporting of statistically significant primary outcomes over non-significant ones; and are often not acknowledged in final publications.
Original trial was preregistration, the trial publication is BMJ.
Design Bibliographic analysis of trial publications.
Four retention trial publications contained two trials each.
If this is confirmed in the final publication of the trial then it adds further importance to the use of a non invasive assessment of lymph node status which would allow a decision to be made on the requirement of adjuvant surgery, which in light of this trial will be the only potential benefit of lymphadenectomy.
The final publication of the results of the trial is still pending.
Finally, all authors have approved the final manuscript for publication.
The final publication of this study as well as the German trial mentioned above should help shed light on the topic.
We believe that the NCT ID should be included in any final publication to allow the reader to evaluate the strength of the trial by comparing it to the original plans as outlined in the registry.
Bind and submit the final publication to the school library.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com