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The final optimization test determining the optimal initial pH is shown in Figure 5b.
This PubChem3D similarity search is a multistep process designed: to filter out conformer pairs that cannot possibly be neighbors, to generate a near-optimal superposition between conformer pairs, and to perform a final optimization of the superposition to maximize the shape volume overlap between conformer pairs.
The results of optimal designs called 'Pareto-optimal solutions' are a set of multiple optimum solutions, from which the final optimization can be chosen after sensitivity analysis is performed.
The media optimized by L27OA method was used as an input for CCD for final optimization.
Final optimization of formula was performed by response surface methodology using a central composite design.
A final optimization of the significant factors was carried out using a Doehlert matrix.
A final optimization of the micro-PEG assay established that amounts as low as 0.1-0.2 0.1-0.2be used.
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Final optimizations lead to SAR184841 with good oral pharmacokinetic properties showing in vivo activity and improvement of metabolic parameters in a physiopathological model of type 2 diabetes.
The GMM analyses were implemented with 200 random sets of starting values and 20 final optimizations.
As a final solution optimization of the HVAC system is presented.
A fractional factorial response IV design was employed for the identification of the significant factors and a five-level circumscribed central composite design for the final method optimization.
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