Sentence examples for final executioner from inspiring English sources

In addition to the anti-oxidative effect of adiponectin, we also found an anti-apoptotic effect of adiponectin in lowering the activity of caspase 3, one of the final executioner proteins in the apoptotic cascade.

Caspase-3 is the final executioner enzyme that, when activated, destroys structural proteins of a cell.

For assessment of apoptosis, we identified the activation of caspase-3, which is the common final executioner caspase for the apoptotic pathways.

To this aim, the levels of the anti-apoptotic Bcl-2 or Bcl-XL or the pro-apoptotic Bax proteins, Cyt c release into the cytosol and the activation of the final executioner caspase-7 (Santha et al, 2013; Charalambous et al, 2013), occurring in a mitochondrial apoptotic pathway (Kaufmann and Hengartner 2001), were analysed.

Caspases are the final executioners of apoptosis and their activation requires proteolytic processing of inactive zymogen into activated fragments.

As caspase-3 and -7 are the final executioners of apoptosis, both inhibition and activation of catalytic activities are of significant interest as therapeutic strategies for neurodegenerative diseases and cancers [ 5, 15- 18].

Prevention of this apoptotic injury with inhibitors of the caspase enzymes [ 47], regarded as the final executioners in apoptosis or of over expression of anti-apoptotic proteins, has been shown to improve survival in animal models of less acute sepsis.[ 2, 3] Critical mediators of this septic apoptotic injury include pro-apoptotic proteins such as BAX and activated caspase-3 [ 2, 3].

Even the very smallest roles were played brilliantly, such as this final episode's executioner, established by Philippe Spall, within the space of a few minutes and fewer lines, as a man with professional pride and no little compassion; the person you would want on your side if you ever had to mount the scaffold to clear the way for Jane Seymour.

On January 2 1981 I was on the final pages of The Executioner's Song, which I had read at a gallop.

Soon he began to stand in the cold shadows of Piazza Maggiore, awaiting a criminal's final date with the executioner.

The show revolved around Radvanovsky and her warm stage presence made her final climb up the executioner's scaffold an unexpectedly poignant moment, despite the churning, relentless orchestral accompaniment playing the theme from Maria's cabaletta, "Nella Pace del Mesto Riposo," that was lead with balance and style by Maestro Riccardo Frizza.