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Nevertheless, even though our final enrolment of participants (n = 89) was less than the calculated target (n = 102), it still provides 90% power to detect statistically significant differences between the intervention and placebo groups.
Ellenberg [ 18] argues that information involving the selection process should be obtained at each stage of selection, beginning with the screening of potential participants and proceeding to the final enrolment of those who agree to take part.
Assuming a 25% dropout rate of patient-caregiver dyads, the study needed a final enrolment of 190 dyads in each group, so that at least 48 professionals needed to be randomized to each group.
Data are means±SD, n or median (interquartile range) Patients From May 2003 to July 2005, 857 type 2 diabetic patients were screened at 74 centres in Japan and three centres in Hong Kong with a final enrolment of 577 patients (377 Japanese and 200 Chinese) (Electronic supplementary material [ESM] Fig. 1).
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The final enrolment included 1,672,455 individuals.
In case of 2 or more with a pCR, the study would be continued until the enrolment of final sample size.
All patients were followed up for survival until death due to any cause, withdrawal of consent or 3 years following enrolment of the final subject.
The final analysis would be carried out 12 months after enrolment of the last patient.
The enrolment of the required sample size was completed in May 2013 and the final results are expected by the end of 2014.
PB participated in the design of the study, enrolment of participants, carried out the statistical analyses, wrote the manuscript and approved the final version for publication.
This translates to a net enrolment ratio of 90%.
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