Although GTA is less sparing (less economical) with respect to conflicting markers (hence, fewer markers will remain in the GTA consensus maps than in the synchronous-TSP maps), if the two approaches perform well, the subset of markers remaining in the final consensus maps from the two methods are expected to be in the same order.
Feedback was sought from the stakeholder panel, and the outcome categories and coding were modified based on the final consensus of the stakeholder panel.
Subsequently, native Spanish-speaking clinical experts from Latin America and Spain reviewed the document for content and accuracy of clinical terminology and achieved a final consensus with the original translator.
Completion of the back-translation resulted in draft formats with a final consensus version gained from both translators.
The map distance between markers in the final consensus map ranged from 1.0 to 27.8 cM and the overall mean was 3.5 cM, which is much smaller than the overall mean distance (6.1 cM) of the population specific maps.
The final consensus tree was inferred from 1000 bootstrap replicates.
This paper also gives the final consensus values, which is different from the existing works on the quantized consensus of second-order multi-agent systems.
We were able to compare the final consensus diagnoses with autopsy results from seven individuals who had consensus clinical diagnoses of Probable or Possible AD (n = 6) or 'demented, questionable etiology' (n = 1).
These patients were not included in the final analysis, as the cohort analysed was derived from the final consensus diagnosis made at follow-up.
In addition, we removed LG 2 and LG 7 maps for G0 families F20 and F45 from the final consensus map, because they fit a preliminary merged map poorly; likewise, we removed F12 and F20 framework maps from the final consensus map for LG 10.
The initial consensus map consisted of 961 markers but about 55% of the SNPs (531 of the 961 SNPs) had a map distance < 1 cM to adjacent markers, so they were excluded from the final consensus map.
