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Nephrin is a podocyte slit-diaphragm protein that functions in the kidney glomerular filtration barrier.
Podocytes are specialized cells that contribute critically to the normal structure and function of the glomerular filtration barrier.
Despite this severe charge disruption, the glomerular filtration barrier was not compromised, even when challenged with bovine serum albumin overload.
Podocytes are highly specialized epithelial cells with complex actin cytoskeletal architecture crucial for maintenance of the glomerular filtration barrier.
Furthermore, these results suggest a novel link between epithelial polarization and the maintenance of a functional filtration barrier.
Collectively, GEnCs, the GBM and podocytes together constitute the glomerular filtration barrier [4] [6].
Podocytes are uniquely structured cells that are critical to the kidney filtration barrier.
Injury to or disruption of any of its constituents compromises the integrity of the glomerular filtration barrier resulting in proteinuria.
Together with the glomerular basement membrane (GBM) and endothelial cells, they comprise the glomerular filtration barrier of the kidney.
(A ) Cartoon showing the glomerular filtration barrier.
Microalbuminuria results from the increased passage of albumin through the glomerular filtration barrier.
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