Using these decoys, together with the filtered actives from Good and Oprea, would introduce a bias of an artificial enrichment based on the distinction of physical property values.
On the other hand, filtering actives against DUD and random ZINC decoys led to a clear dependency between MCC and the number of models: the higher the number of models included in the profile, the higher the MCC values.
To remove this artificial enrichment bias, we applied the same lead-like filter, used by Good and Oprea to filter the active structures, on the decoys.
Several studies address this problem by incorporating gene expression information to filter the active interactions.
Although the proposed approach is applicable for any passive filters configuration, an L-filter active rectifier is used as the test system.
Signal noise was reduced by using EMI filters, active filters and metal shield.
This chapter discusses two kinds of filters, active and passive, along with filters that are used in sine or continuous wave circuits.
For those filtered assays, active compounds whose dose response value was equal to or lower than 10 μM were kept as active entries and others were removed.
The growth chamber has an easily renewable filter, and the incoming indoor ambient atmosphere is filtered with active charcoal (CF) or with equally sized inactive particles (NF).
We removed all antibiotics with known mechanisms of action and filtered the active molecules for diversity in chemical structure.
