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It is demonstrated that filling this pocket can confer ligands with dramatically enhanced affinity for Chk1.
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The goal of the present study was to identify new fragments which fill this hydrophobic pocket and might be interesting chemical moieties to design new inhibitors.
He also said that Samsung ran a bribery network, filling the pockets of prosecutors, bureaucrats and politicians with cash gifts.
Fabrication of the electrodes is achieved by filling the pockets of a molded polydimethylsiloxane structure with liquid metal.
That we value filling the pockets of the rich while robbing from the poor?
Thus, the presence of a hydrophobic substituent to fill the pocket created by movement of the αC helix is necessary to stabilize this inactive conformation.
Crystals of other NR LBDs reveal that the pocket can expand or contract and some agonists do not fill the pocket.
This money flowed into the economy, where once it would have filled the pockets of shareholders, many of them pension funds.
IT IS better to settle a case than to go to court only to fill the pockets of lawyers.
Mr. Bloomberg said the law was being abused to "fill the pockets of bootleggers and crooked cigarette dealers".
I was in charge of my own ammunition so I borrowed a gun vest and filled the pockets with shells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com