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A random sample of one million records was drawn from the Subsample Inpatient Core File for the study (924 hospitals).
To create the cohort, we used the Medicare enrollment file for the study period, which provides a listing of all Medicare enrollees, along with demographic information (age, race, and sex) and ZIP code of residence.
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The rules for naming the four file formats defined in the ISA-TAB-Nano specification are i_xxxx.txt for the Investigation file, s_xxxx.txt for the Study file, a_xxxx.txt for the Assay file, and m_xxxx.txt for the Material file, where 'xxxx' denotes a unique string.
See Supplementary files for the study protocol.
See Additional file 1 for the study's PRISMA checklist.
See Appendix D (Additional file 2) for the study designs and detailed results.
LT and KR constructed the analytic file used for the study, operationalizing study concepts and linking them to specific research questions.
RF, GL, and BJ constructed the analytic file used for the study, operationalizing study concepts and linking them to specific research questions.
Electronic sheets were verified at the end of data collection to eliminate data entry errors and were subsequently entered into a computerized database, which represented the source file for this study.
The population-level VCF file for this study was examined for relevant variation in these two genes.
For treatments applied in 2009, a shorter than three-year after period was defined as accident files available for the study were limited by 2011.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com