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Finally, boundary conditions constrained to experimentally derived figures from the primary literature (Additional File 3) were added to the model to reflect the import and export of metabolites into the system from the cytosol of both common metabolites and the metabolite orphans present in the cytosol compartment.
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We additionally left censored woman years at risk in the episodes with cervical intraepithelial neoplasia (a in figure) from the primary test until the third consecutive normal smear test result because women were still being followed-up and no cervical cancer was by definition diagnosed during that period.
Based on the proposed simplification criteria in the Materials and methods section, the simplified BN from NAFLD to MetS retained 14 nodes, 33 edges and 36 pathways (shown in figure 3) from the primary network (see online supplementary figure S1).
We first addressed the question whether the spatially separated foci (the four analyzed lesions were designated as A to D; Figure 1a) from the primary tumor were clonally related.
All data shown in the following figures are derived from the primary dataset.
Motifs in figure 4 were deduced from the primary sequence of the LGRs shown in supplementary figure S4, Supplementary Material online.
Human figures were the primary subject.
A significant increase in HSF1 protein level and mRNA (Supplementary Figure 1A) was detected from the primary tumours to metastases.
Figure 1 shows the results from the primary analyses using a multivariable proportional odds logistic regression model of the VES-13 score.
We then plotted the death index for each siRNA from the primary screen (Figure 2).
Anti-SV40 antibody, which stained tumor cells only, and anti-cathepsin antibody staining patterns were mutually exclusive, indicating that cathepsin-positive cells within the stroma were not tumor cells that had detached and migrated away from the primary mass (Figure 2E G).
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