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BiO checks figures for evidence of image manipulation (Rossner and Yamada, 2004).
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See Figure 4 figure supplement 1 for additional tests of 3-IB-PP1 specificity for CskAS, Figure 4 figure supplement 2 for evidence of that 3-IB-PP1 cotreatment suppresses signaling through the CSF-1 receptor, and Figure 4 figure supplement 3 for evidence that actin-remodeling agents cannot restore 3-IB-PP1-induced downstream signaling.
We examined the genomic regions of fish matrilin-3s, as shown in Figure 6, more closely for evidence of syndecan-1 coding sequence.
The ClustalW alignment of all strains (except E. albertii) (see Additional File 3, Figure S2) was analyzed for evidence of sequence acquired by recombination using GENECONV [ 26] with command-line parameter gscale = 1.
To account for other mechanisms that could result in elevated insulin reporter activity, we examined a second group of 23 strongly implicated drugs (SSMD values ≥1.75, Figure 2D, 'Hit II' subset) for evidence of increased β-cell numbers in the absence of differentiation effects.
Plates were examined daily (on weekdays) for evidence of growth (figure 4).
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