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c CT findings of the left lower fields of the lung.
b CT findings of the right lower fields of the lung.
We quantified the stained area in 10 random non-coincident microscopic fields of the lung parenchyma in each slide (one slide/animal).
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These annotation-based clusters suggest that functionally different genes expressed in susceptible fields of the lungs eventually contribute to the formation of either fibrosis or emphysema, depending on the pattern of gene expression in that field.
Atypical honeycomb lung was noted significantly in the subpleural portion and lower field of the lung on computed tomography (CT).
Recurrent lesions were located in both the primary irradiated field of the lung and in distant organs such as the brain or bones.
In an EPMA analysis field of the lung biopsy specimen from upper lobe fibrosis, we found tungsten scattered throughout the fibrosis as well as aluminium, silicon and titanium.
Principally, low field MRI of the lung can be performed with T1-weighted GRE and T2-weighted FSE sequences.
Five µm sections were H&E stained and fibrosis was evaluated under 400× magnification by a pathologist, blinded to the nature of the mice, scoring each field of the entire lung section according to the following criteria; 0: no fibrosis, 1: 0 to 25%, 2: 25 to 50%, 3: 50 to 75% and 4: 75 to 100%, as previously described [21], [25].
Briefly, all the fields of each lung section were scanned under a Leica microscope at a magnification of × 100, then each field was visually graded from 0 (normal lung) to 8 (total fibrotic obliteration of the field).
Advances in the fields of lung cancer chemoprevention and therapy have the potential to reduce lung cancer related mortality.
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