These findings provide new evidence for the hypothesis that significant adaptational changes in the speed and fidelity of responses occur at the level of light-gated ion channels [8], [57].
Inhibitory circuits can have a profound impact in the processing of afferent activity (Markwardt et al., 2009; Isaacson and Scanziani, 2011; Ikrar et al., 2013); for example, they can ensure a temporal fidelity of responses (Pouille and Scanziani, 2001) and also modulate neuronal firing in response to afferent inputs (Pouille et al., 2009; Dieni et al., 2013).
We predicted that children who completed FFW exercises would show improvement in the neural encoding of speech syllables, including faster response timing, greater fidelity of the response relative to the stimulus, and more accurate pitch encoding over time.
Because the simulation provides high fidelity evaluation of response times and workloads using data from actual CFS it is a time intensive process.
The broadband characteristics of the antennas are achieved by loading the wires with combinations of passive loads, trying to maximize the fidelity of the response while keeping the efficiency as high as possible.
Upon ScTx application however, the fidelity of the response was substantially improved at both frequencies and neurons followed the stimulation train much more efficiently.
In addition, in cells expressing numerous KCa3.1 and Orai channels, there would be enhanced sensitivity to low grade stimuli, thus increasing the dynamic range, specificity and fidelity of the response to an external stimulus.
Stimulation consisted of a 10 ms vertical deflection of a single whisker contralateral to the recording site, delivered at 1 Hz (50 stimuli applied per stimulus intensity to account for the low fidelity of cortical responses) using a fast piezoelectric bimorph wafer attached to a lightweight glass capillary driven from a voltage source (DS-2, Digitimer) under the control of Spike2 software (CED).
This may provide a basis for explaining the length of biological reaction cascades as a compromise between demands for fidelity and speed of response.
