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There were bundles of collagen surrounding the lobules that resulted in large fibrous septa and distorted tissue architecture.
When liver fibrosis occurs, the accumulation of this type of collagen is enhanced, particularly in the fibrous septa [88, 89].
Lobules were separated by fibrous septa and were composed of mature adipocytes and vacuolated lipoblasts showing varying degrees of differentiation.
Histologically, the lesion consisted of thin fibrous septa with a plexiform vasculature and prominent myxoid or mucoid matrix.
It was well circumscribed, and the cut surface was pale yellow and heterogeneous with fibrous septa (Fig. 2a).
ABC is a benign, expansile, non-neoplastic lesion of the bone, characterized by channels of blood and spaces separated by fibrous septa [1].
Favouring the diagnosis of a FNH-like lesion is the presence of a central scar and/or a network of fibrous septa carving the nodule into smaller lobules.
No SA-βgal activity was evident in the fibrous septa.
Fibrous septa of variable size were present; these hepatocytes had a variable immunohistochemical expression of nuclear proliferation factors and fetoproteins (data not shown).
In the three cases with liver cirrhosis, the senescent hepatocytes were found predominantly around the regenerative nodules or inside of them (in lesser proportion) and absent in the fibrous septa.
Scarring, broad fibrous septa and extensive central necrosis were also observed.
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