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NFT are intracellular fibrous inclusions composed of paired helical filaments (PHFs) of aggregated and often hyperphosphorylated tau [ 9].
Human liver affected by chronic alcoholism had fibrous inclusions measured up to 3 µm in length in the mitochondrial matrix (Svoboda and Manning, 1964).
Wrought iron is an iron alloy with a very low carbon content (0.1 to 0.25 wt%) that has up to 2.0 wt% fibrous inclusions (slag).
On the other hand, rat liver cells that were injected with ethanol had fibrous inclusions in the matrix or intermembrane space between inner and outer mitochondrial membranes (Iseri et al., 1966).
There is a possibility that advanced stages of GVD could be mistaken for NFT, as seen in Figs. 1 and 2. The CA2 area at low power in Fig. 1 appears to contain at least three neurons with robustly staining cytoplasmic inclusions, but at higher magnifications only one neuron from the marked area contains NFT, with others showing advanced GVD or a combination of GVD-like and fibrous inclusions.
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Intramitochondrial fibrous inclusion bodies also occurred in pathological conditions.
In the last three decades, three electron microscopic observations on the intramitochondrial fibrous inclusion bodies of yeasts have been reported (May, 1974; Nagano et al., 1982; Yotsuyanagi, 1988).
In human liver cells (Wills, 1965), rat kidney cells (Suzuki and Mostofi, 1967), and rabbit thyroid gland (Nathaniel, 1980), fibrous inclusion bodies were localized to the matrix of mitochondria.
A method of engineering the microstructure of brittle composites is proposed and tested that improves the effectiveness of non-fibrous inclusions to bridge cracks in the matrix.
This enhanced oligomerization increases the tendency of α-synuclein to form β-sheet structures and eventually fibrous amyloidogenic inclusions, called Lewy bodies and Lewy neurites (Lesage and Brice, 2009; Martin et al., 2011; Roostaee et al., 2013).
SFT lack the whorls, psammomas, nuclear-cytoplasmic inclusions and fibrous vessels present in meningiomas.
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