Exact(7)
For VLU, wound bed preparation consists of debridement of any slough, necrotic, and possible fibrotic material.
The ischaemic glomeruli are characterised by wrinkling and collapse of glomerular capillary wall associated with extracapillary fibrotic material [ 17].
Untreated paws displayed excessive inflammation, deposition of dense collagenous fibrotic material, disorganization of elastic fibers, and thickening of the dermis, as compared to wild-type paws (Fig 2).
This environment limits muscle regenerative capacity and there is concomitant replacement of formerly functional muscle fibres with adipose and fibrotic material (reviewed in [ 1]).
However, the persistence of an inflammatory stimulus in adipose tissue may be responsible for the excessive synthesis of ECM components and subsequent interstitial deposition of fibrotic material.
Even correct placement of the needle within the tumour mass does not guarantee that the sample will contain viable tumour cells, because tumours contain large areas of necrotic and fibrotic material.
Similar(52)
In most lungs that show the ELS, we do not observe either the presence of substantial numbers of inflammatory cells or accumulations of fibrotic materials.
Moreover, in three of four responding patients, by week 12 and at following biopsy time points, tumour had disappeared (two patients) and biopsies contained only fibrotic materials (one patient).
The central necrotic or acellular zone showed three different morphological manifestations as described above, characterized by: (i) coagulative necrosis; (ii) fibrotic, hyaline material or scar tissue; and (iii) infarction.
The microscopic examination of necrotic mesenteric lymph nodes revealed a central homogeneous acidophilic material, fibrotic walls and rare lymphocytes and plasmocytes in the periphery.
The histopathological examination of the samples revealed central homogeneous acidophilic material, fibrotic walls with a rim of normal lymphocytes at the periphery of necrotic lymph nodes and no signs of malignancy or infection.
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