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Fifth, although the AA index can be accurately used to predict significant fibrosis, it cannot truly replace histological fibrosis staging.
Stepwise logistic regression with the accompanying C statistic was used to determine factors associated with moderate to severe necroinflammation (grade ≥9 points) or fibrosis (staging ≥3 points).
In our study, although the absolute percentages suggested a higher proportion of children with both advanced necroinflammation (grade ≥9 points) and fibrosis (staging ≥3 points) among the coinfected patients (10%%) compared to both control groups (3 % in both groups), the observed difference did not reach significance, probably due to the small numbers of patients in each group.
Shear wave elasticity imaging (SWEI) has found success in liver fibrosis staging.
However, the researchers did not study whether 99mTc-3PRGD2 could be used for fibrosis staging.
Thus accurate fibrosis staging, especially the diagnosis of cirrhosis, is needed in clinical practice to determine the urgency and need for anti-HCV antiviral therapy [5, 6].
Similar(5)
TE-derived fibrosis scores correlate with Metavir fibrosis staging system as follows: <7.1 = stage 0 1, 7.1-9.4 = stage 2, 9.5-12.4 = stage 3, and ≥ 12.5 = stage 4. The fibrosis stage predicted by TE has been shown to correlate with the histologically determined fibrosis stage [ 17].
Finally, the association with NAFLD fibrosis stage was tested.
Liver fibrosis stage (F0~F4) is according to the METAVIR scoring system.
Table 1: Multivariate analysis of association between TM6SF2 rs58542926 genotype and fibrosis stage F0 1 (mild) versus F2 4 (advanced).
Only 2 patients with liver fibrosis stage 2 were incorrectly classified.
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