Sentence examples for fiber knob from inspiring English sources

Coughlan, L. et al. Retargeting adenovirus serotype 48 fiber knob domain by peptide incorporation.

Wang, H. et al. Identification of CD46 binding sites within the adenovirus serotype 35 fiber knob.

For equilibrium binding analysis, the HAdV-D26K and HAdV-B3K fiber knob proteins were purified and concentrated to 367 and 3 μM respectively.

In the latter, an RGD peptide, the binding site for αvβ3 and αvβ5 integrin, was introduced in the fiber knob enabling adenovirus receptor-independent viral infection.

We reduced this leakage through genetic modification of the vector capsid to display RGD and poly-lysine motifs in the fiber knob.

This is normally achieved through either engineering of the viral fiber knob or the use of bispecific adaptors that display both adenovirus and tumour antigen receptors.

A similar dissociation constant (Kd = 3 nM) has been reported for the S11 anti-fiber knob scFv used in some diabody strategies [31], [32], [37].

SPR analysis of the interaction between recombinant fiber-knob protein with CD46 confirms these findings.

Fiber-knob dilutions were then added to the cells and incubated on ice for 30 min.

The work undertaken in this study presents, for the first time, the crystal structures of the fiber-knob domain protein of HAdV-D26 (PDB: 6FJN), and HAdV-D48 (PDB: 6FJQ) fiber-knob protein.

We next calculated the amino acid variability at each position in the aligned adenoviral fiber-knob sequences, which revealed regions of broad conservation corresponding to β-strands which make up the main fold of the fiber-knob trimer (Fig. 1d).