Apart from these two extreme cases, the remaining Israeli patients (HM1 and HM5) showed a wide range of pathology: completely preserved fibers alongside fibers with prominent lysosomal enlargement (diameters exceeding 7 μm; Figure 7c; arrowheads; pt. HM1), autophagic buildup, and autofluorescent inclusions.
This finding supports the theory that higher amplitude stimulation leads to recruiting of larger volume of tissue, therefore larger number of fibers, as demonstrated in this fiber tracking study of enlargement of the volume of tracking surrounding the stimulating lead.
Autonomic symptoms could derive from the stretching and disruption of the pericarotid sympathetic nerve fibers, due to the enlargement of the vessel by intramural hematoma [9].
Within the granular layer, a mossy fiber generates a series of enlargements called rosettes.
The ultimate size of a fish is shaped by the balance between recruitment and enlargement of muscle fibers and water temperature is one of the main constraints affecting muscle phenotype but the molecular basis of such phenotypic plasticity is still poorly understood.
Transgenic cotton overexpressing GhRDL1 showed an increase in fiber length and seed mass, and an enlargement of endopleura cells of ovules.
In populations of muscle fibers expressing fast and/or slow MHC s) but not developmental MHC of CXMDJ muscles, slow MHC fibers were predominant in number and showed selective enlargement.
The ratio between the amplitudes of the larger and the smaller climbing fiber-evoked EPSC increases in parallel with the decline of the polyinnervation factor, indicating a gradual enlargement of the synaptic contribution of the winning climbing fiber synapse at the expense of the losing one.
The expression of XET and expansins was about 100-fold higher in cotton fiber cells, corresponding to their proposed role in cell enlargement [ 49].
The rectangular enlargement was used to simulate the possible relationship between fiber distance and voltage; larger voxels would capture fibers that were stimulated at higher voltages and possibly adverse side effects.
