Neurites extended radially on random scaffolds, whereas aligned scaffolds directed neurite outgrowth for all fiber dimensions.
We present pore and fiber dimensions based on confocal microscopy and longitudinal modulus and hydraulic permeability based on confined compression.
Topographical features, including fiber dimensions and pattern, are important aspects in developing fibrous scaffolds for tissue engineering.
The numerical simulations show that the stress distribution along the fiber surface varies substantially with temperature and fiber dimensions.
Furthermore, the effect of electrospinning parameters, such as solution concentration, applied voltage, collecting distance, and rate of spinning, on the fiber dimensions and morphology are studied.
Fibrous scaffolds, with fiber dimensions on the nanometer scale, are ideal for tissue engineering applications as they can mimic the physical structure of natural extracellular matrix.
A piezoelectric polymer polyvinylidene fluoride trifluoroethylene (PVDF TrFE) was used to fabricate electrospun aligned and random scaffolds having nano- or micron-sized fiber dimensions.
Neurite extension was greatest on aligned, annealed PVDF TrFE having micron-sized fiber dimensions in comparison with annealed and as-spun random PVDF TrFE scaffolds.
Very good correspondence is found between F.E. results and microscopic cross-sections, showing the usefulness and applicability of the method to random lay-ups and optical fiber dimensions.
The amphiphilic triblock copolymer PLA PEG PLA (PELA) improved the stability of HA PELA suspension at 25 wt.% HA content, which was readily electrospun into HA PELA composite scaffolds with uniform fiber dimensions.
The trade-off depends on not only the operating variables, such as the temperature and the flow rate of the cold solution, but also the fiber dimensions, such as the fiber length and the packing density.
