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Very little information is available on actual fiber clearance rates from human lungs.
Therefore, no half-time of the fiber clearance could be calculated from the number of fibers.
This "biopersistence" of fibers is limited by two main mechanisms of fiber clearance: removal by macrophages after phagocytosis and, for some fibers, by actual dissolution.
Fiber clearance studies with Kevlar showed a transient increase in the numbers of retained fibrils at 1 week postexposure, with rapid clearance of fibers thereafter, and retention half-time of 30 days.
Similar(56)
Additionally, persistent mitotic stimulation of mesothelial cells after direct physical insult, and reactive oxygen species generated by the fiber clearance-related cellular response, may induce a reaction by mesothelial cells akin to that of cells in culture subject to repeated cycles of growth.
Neutral detergent fiber (NDF) fractional clearance rate (Kcl) and fractional degradation rate (kd) of six varieties of perennial ryegrass were measured to examine the possibility of selecting for varieties with fast degradable NDF.
Most data are consistent with a better clearance of fibers < 5 μm compared to fibers > 5 μm and > 20 μm.
The half-life of the fibers was calculated using a model taking into account the rapid early clearance of fibers (weighted half-time) (Additional file 2: Table S5).
After a period of one day, the authors reported a low clearance of fibers longer than or equal to 16 μm, while short fibers were quickly removed.
With this animal model the role of biopersistence in altering the geometry and clearance of fibers can be systematically evaluated.
An interesting system to study the effect of fibers in a clearance-like period of time would be the "in vitro" treatment followed by recovery periods.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com