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Vaccinated animals developed fewer plaques than their untreated littermates.
They found that the dogs on the diet had developed around 40% fewer plaques.
The drug appeared to prevent some plaques from forming: The animals developed fewer plaques overall; some 30% had no detectable plaques at the age when untreated rats' brains are riddled with them.
Despite the antioxidative function of Nrf2, we observed that ApoE−/− Nrf2−/− mice developed fewer plaques than ApoE−/− controls.
By comparison, H-type BSE cases showed fewer plaque-like deposits, and the grey matter of the cerebral cortex displayed prominent stellate labelling in addition to particulate forms.
mC2 also bound but fewer plaques were labelled (Fig. 1c).
There appeared to be fewer plaques in the NIr-treated APP/PS1 brains.
As expected, three of the clinically diagnosed AD patient showed extensive plaque load whereas one clinically diagnosed AD patients showed fewer plaques compared to the other AD patients.
The WT brain is free of plaques; many 4G8+ plaques (arrows) are present in the neocortex and the hippocampus of untreated APP/PS1 mice, and fewer plaques are present in NIr-treated APP/PS1 mice.
Later, the large number of plaques may serve as "dumps" for free Aβ, so that its concentration gradually drops, causing the formation of fewer plaques during the transition phase, while existing plaques continue growing.
Further analysis of 11-month-old animals using the β1 antibody (used for passive immunization) showed that treated animals exhibited fewer plaques stained with β1 indicating epitope masking (Fig. 3 and Additional file 3: Table S3d).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com