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In contrast, the wMel infection causes somewhat weaker blockage of dengue and other viruses than wMelPop, but has fewer deleterious effects as well as having a lower titre in adults (Walker et al. 2011; Hoffmann et al. 2014a).
This study shows that loss of SAFB2 has fewer deleterious effects compared to loss of SAFB1, but analysis of the SAFB2 –/– phenotypes suggests a role for SAFB2 in the male reproductive system.
Based on the results from the Mdm2 and Mdm4 deletions in mice, the inhibitors targeting Mdm2 may cause lymphocyte and epithelial defects when the inhibition reduces Mdm2 efficacy to 30%; therefore, Mdm4 inhibitors in cancer patients may be a more desirable choice due to the fewer deleterious effects on normal tissues.
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Interestingly, Tol2 can also be used as a transgenesis vector in medaka, since expression of Tol2 transposase has no or very few deleterious effects on the medaka genome (Takehana et al. 2014).
Phase 1 and phase 2 clinical trials were successful and established maribavir as having fewer deleterious side effects than current HCMV treatment options.
Therefore, the classification of mutations as deleterious depends greatly upon the genetic background into which that mutation is incorporated, and fewer mutations have deleterious effects in genetic backgrounds with poor fitness [44].
The targeted gene knockout studies reported here support the conclusion that the development of therapeutics that impair cell division by inhibiting, but not fully blocking, key regulators of the cell cycle machinery (CDC25s) may have fewer deleterious GI side-effects than chemotherapeutic agents that block cell division by inducing DNA damage.
The report also noted concerns about the District's conclusion that the water withdrawals will have few deleterious ecological effects.
Contrastingly, only a few articles have addressed the deleterious effects of TBT in crustaceans [ 12].
As evidenced above, few studies have reported the deleterious effects of fatigue on stroke performance, or, more simply the changes in stroke performance/outcomes following highly repetitious stroke and movement production.
Some subtle differences appear due to the high concentration of free Ub ameliorating the deleterious effects of a few mutations on E2-to-E3 Ub transfer, potentially due to Ub's noncovalent association with the HECT domain N-lobe stabilizing the E2 binding site.
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