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Relative to PBS-treated mice, rhGas6-treated mice had fewer activated microglia in the corpus callosum by Iba1 immunostaining.
This is clearly seen in most SLE patients, but healthy individuals typically have substantially fewer activated lymphocytes.
We also observed a decrease in number but not percentage of CD44hiCD62LloCD4+ cells, indicating fewer activated effector CD4+ T cells.
Prtg-deficient R-CNCCs display fewer activated α5 β1-integrins in embryos, and these cells show reduced migratory ability in in vitro transwell assay.
Recent work has shown that multi-fluorophore images can also be analyzed to obtain fluorophore position information [ 23], in which case one would want to maximize the number of images with mmax or fewer activated fluorophores.
As expected, we observed significantly fewer activated primordial follicles in Lhx8 flx / flx Lin28a flx / flx Gdf9Cre compared to Lhx8 flx / flx Gdf9Cre ovaries, but they were not completely normal compared with the control (Fig. 5a, b, d, f).
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One of the reasons for this is thought to be due to limited expression of the gene product involved and few activated antigen presenting cells.
In general were very few activated (Fos+) hilar mossy cells or interneurons in the vehicle-treated animals (Vehicle: Fos only+: 144 ± 55 cells/mm, n=4, Fos+/GAD67+: 14 ± 16 cells/mm, n=4).
CGAS values among melanoma cell lines did not show a normal distribution (D'Agostino and Pearson omnibus normality test: p value =0.0012) but rather indentified a group of 15 cell lines with no or only few activated CG genes (CGAS ≤2) and another group of 22 cell lines with a CGAS ≥7 (Fig. 1a).
Importantly, specific sub-states within the stem cell state are closer to certain downstream cellular fates than others; indeed fewer activating triggers ('pushes') are needed and shorter transition paths exist when starting from these sub-states.
Since CCL18 is secreted by dendritic cells upon recognition of M. tuberculosis [ 48] and has been implicated in differentiation of macrophages into an alternative phenotype [ 49] this suggests that decreased CCL18 levels lead to fewer alternatively activated macrophages and less T-cell regulation [ 6, 50].
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