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Few trials addressed the extent to which the care in stroke units differed from the care in general medical wardsa.
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There are a few trials addressing the emergency care of older people, mainly focusing on post-discharge support [ 10], with relatively few that address the care of older people within the ED itself [ 9].
Even when the few trials addressing cord insulin or C peptide have not shown any difference, we can only understand the results in the glibenclamide versus insulin comparison in terms of more fetal hyperinsulinism in the glibenclamide arm.
Further preventive strategies include the reduction or avoidance of other known risk factors but only few randomized trials addressing these are available.
However, despite the outstanding relevance of hormonal adjuvant therapy in breast cancer and the importance of receptor status as a predictive factor, few trials have addressed these issues in ovarian cancer.
Finally, although there are few trials specifically addressing symptomatic control and quality of life, it is generally agreed that tumor shrinkage is associated with better control of symptoms, and that quality of life results from the balance between activity and tolerability of treatments.
Despite intense debate regarding whether new techniques for knee arthroplasty improve clinical outcomes over standard techniques, few prospective randomized trials addressing this debate are available in the literature.
Few high-quality trials addressing the benefit and impact of clinical pharmacy services in CKD and ESRD patients have been published.
All trials addressed clinically suspected VAP.
The few trials to date addressing the optimal approach to preventing haemorrhage at caesarean section have been under-powered to evaluate clinically important outcomes.
The greater use of taxanes over the past few years has been described in the literature, with a number of trials addressing the benefit of adding a taxane (paclitaxel or docetaxel) to an anthracycline-based adjuvant chemotherapy regimen [ 26- 30].
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