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Such a drug should have few systemic side effects and its delivery should be optimized so as to encourage compliance.
The procedure allows a high locoregional concentration of cytostatics with few systemic side effects [ 2].
8 Topical prostaglandins such as latanoprost, bimatoprost and travoprost are similar in that they require once-daily instillation, produce few systemic side effects and reduce IOP levels similarly.
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However, applying doxorubicin locally vs systemically could lead to fewer systemic side effects such as cardiomyopathy.
Prilocaine was determined, in the 1960s, to have fewer systemic side effects and contributed to a resurgence of Bier's technique [ 16, 21].
Many theoretical advantages of nebulized antibiotic therapy have been proposed, such as higher drug levels at the infection site and fewer systemic side effects [ 7].
SDD may have fewer systemic side effects and thus can be given to critically ill patients to prevent Candida colonisation and infection.
Intra-articular injections appear to be preferred over systemic steroid applications for TMJ management in both JIA and RA [ 7], presumably because of more localized action and fewer systemic side effects and less impact on other bones of the skeleton [ 8].
Aclidinium, however, has been shown to undergo more rapid hydrolysis than tiotropium in human plasma (34, 35) and could, therefore, be considered to have the potential for fewer systemic side effects than tiotropium.
We found that laser at a specific setting increased the motility of antigen presenting cells (APCs) and immune responses, with few local or systemic side effects.
13– 18 Long-term studies have shown that ranibizumab is well tolerated for over 4 years and has been shown to have very few serious ocular and systemic side effects.
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