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SIRT5 is the third mitochondrial sirtuin protein with very few substrates identified till date.
However, current experimental constrains limit this classification to a few substrates.
However, since only a few substrates can hold such an extreme synthesis temperature, the deposition temperature of PCF rarely exceeds 1200 °C.
The specificities of some F1SBPs narrowed to relatively few substrates.
However relatively few substrates for mitochondrial Omi are known.
These enzymes share no structural and functional similarities with their eukaryotic counterparts and, to date, only few substrates of BY-kinases have been characterized.
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This result indicates that large DegP cages only enclose a few substrate molecules at a time, even in the presence of a large molar excess of substrate.
The isolation of strain HdN1 along with that of strains OcN1 and HxN1, a few substrate tests, and the capacity for complete alkane oxidation in anoxic medium with NO3− have been documented previously (Ehrenreich et al., 2000).
Another "specialist" clone that was abnormally deficient on fewer substrates was also found in population A+4.
In general, the strains from group A used fewer substrates, 8/95 (8.42%), than the isolates from group B. The first cluster (A) comprises only two slowly metabolizing strains: GL03 and FCL195.
A few reported substrates of CRL7Fbxw8 include IRS-1 (insulin receptor substrate 1) [ 87] that mediates the insulin signalling processes, cyclin D1 that is involved in cell cycle progression [ 88] and also the protein Grasp65 (Golgi reassembly stacking protein 65) that plays a role in regulation of neuronal Golgi morphogenesis and dendrite elaboration [ 89].
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