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While transcription factors often receive high topological scoring due to the significant number of their direct targets in the experimental datasets, the upstream signaling molecules are scored based on the enrichment of sets of their "remote targets"–genes and proteins a few steps downstream on signaling pathways.
Similar(57)
PAINT curators chose to propagate fewer annotations that those transferred by Compara, especially those thought to be several steps downstream from the known molecular function, such as 'negative regulation of neuron apoptosis and spermatogenesis'.
The ovaries in Hr39 and lz mutant females contain a full complement of mature oocytes, however, both lay significantly fewer eggs than controls, indicating that secretory products are required for one or more steps downstream from oocyte completion, such as ovulation, mating, sperm storage, fertilization, or egg laying.
Another few steps.
A few steps upstream.
He took a few steps.
She takes a few steps.
She took a few steps.
She took a few steps back.
"Death is a few steps away.
A few steps back, another officer follows.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com