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This likely explains the failure of cancer treatment with angiogenesis inhibitors (AIs) that target one or a few signalling pathways.
To date, only a few signalling and guidance molecules have been found that directly control their migration, and almost nothing is known about their choice of migratory stream.
A few signalling pathways have been shown to regulate the activity of the Par polarity complex, which include Cdc42 (Joberty et al., 2000; Lin et al., 2000), Ras (Yoshimura et al., 2006), Rap1B (Schwamborn and Püschel, 2004), and phosphoinositide signalling (Jiang et al., 2005; Ménager et al., 2004; Shi et al., 2003; von Stein et al., 2005).
Because of their central role in both development and disease, only a few signalling pathways have received as much scrutiny over the years as Wnt signalling.
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I asked how many had been to Afghanistan previously; only a few signalled yes.
Some of these references were tongue in cheek; few signaled a deep theological commitment.
Consequently few signaling pathways have been characterized completely in trypanosomatids (reviewed in [48], [49]).
Few signaling pathways act in isolation, and the coordination of signal transduction is driven by interactions between pathways.
A receptor for HIMF or its related molecules has not yet been described, although a few signaling pathways have been identified.
Yet few signaling pathways have been identified to be unique solely to Tfh development.
Intracellular signaling molecules play a vital role in regulation of the system output, so blocking one or a few signaling molecules changes the EC fate.
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CEO of Professional Science Editing for Scientists @ prosciediting.com