Their high carrying capacity of 20,000 150,000 drug molecules/liposome, allows for the use of a significantly broader range of moderate-to-high potency small molecule drugs when compared to the comparably few subnanomolar potency maytansinoid- and auristatin-based immunoconjugates.
Using the Muta™Mouse FE1 cell line we determined that the CSCs were clastogenic and cytotoxic, but nonmutagenic, and the results showed few differences in potencies among the three brands.
Natural congeners and synthetic analogues of PTM and PTN have been instrumental in determining their structure activity relationships, with only a few analogues retaining the potencies of PTM and PTN.
When "The Wild Bunch" was rereleased a few years ago, the potency of Sam Peckinpah's imagery did what it was supposed to do: stun, not numb.
Widely considered the "first-in-class" in the HCV drug world, sofosbuvir has a relatively high potency, causes few side effects, and is rarely foiled by drug-resistance mutations.
There is no market mechanism to ensure quality control in the growth or distribution of cannabis, and there exist few methods of testing potency or the presence of other chemical components in pot.
Fosmidomycin is a nanomolar inhibitor of DXR, but despite great efforts, few analogues with comparable potency have been developed.
Although used in numerous investigations in vitro and in vivo, there have been surprisingly few tests of the potency and selectivity of these compounds in cells.
Users must chew great wodges of the leaf, which loses its potency just a few days after being picked.
Nonetheless, the cis configured diammine monochlorido Pt II) complexes exhibited cytotoxic and apoptotic properties on various human cancer cell lines, whereas the trans configured complexes generally showed weaker potency with a few exceptions.
