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It's a "few origins" versus "many origins" argument.
Fracture surface observation reveals that there are a few origins and obvious beach marks, which demonstrates the cracking is a typical fatigue failure and implies there are high stresses at the cracking positions.
"There are very few origins of replication mapped in human cells five to ten if you're generous, but I would say three or four," Dutta says, referring to genetic elements that are necessary to initiate DNA synthesis.
To date, however, PLK mRNA expression has been investigated for a large number of human carcinoma specimens of only a few origins (Wolf et al, 1997; Knecht et al, 1999; Tokumitsu et al, 1999).
In eukaryotes, the process of DNA replication occurs in the S phase of the cell cycle in a highly coordinated manner: it begins with initiation at a few origins of replication, leading to a cascade of origin activation and DNA replication until the entire genome is faithfully duplicated.
This model has been proposed [ 39] for prokaryotes (which have only one or very few origins of replication) and where the genome is much more compact, transcription is less associated with a single gene, and all processes are in the germ-line.
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However, is highly unlikely that a heavy spammer, using a dedicated server farm, would remain in activity without such a technique: it would be easily identified by black lists and blocked, since it uses few origin IP addresses.
There are few origin stories as well known as that of Superman's, his retreat from a dying Krypton leading him to crashland in Smallville, Kansas.
There are a few origin theories, of course, one of which has a pirate from Cuba landing and finding only females on the island, not knowing their husbands were out at sea fishing.
A reduction in the FORK species compared to the wild-type case suggests a slow-down in S-phase because fewer origins are firing within the prescribed time.
It is true that there are fewer origins firing because ORC loading is affected upon ORCA KD, when ORCA is depleted from asynchronously growing cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com