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The growing ineffectiveness of many antibiotics against infection is being compounded by a "discovery void", as few new compounds are being developed to take their place.
However, few new compounds are reaching the market.
There are few new compounds in sight [ 3, 6, 16, 64].
Antibiotic resistance has increased dramatically in the last few years, and very few new compounds have been marketed in the recent years, and will be made available in the next few years [ 2].
A few new compounds are now proceeding to clinical test stages (7, 42), but trypanosomiasis is a complex set of diseases involving various pathogenic species, hosts, and disease stages for which a single panacea is unlikely to be developed.
For a long period, few other drugs were available and it was only after the Second World War that a few new compounds reached the market stage that were both effective and practical, able to effect a cure by a single injection.
Similar(54)
In conclusion, our results demonstrate an optimization of gingerols isolation and their specific anti-proliferative activities against tumor cells, suggesting their use as important models for drug design in an attempt to develop new compounds with fewer side effects when compared to conventional chemotherapy.
These challenges are compounded by the fact that relatively few new drugs are being developed, particularly those that treat resistant Gram-negative organisms [ 22].
We have available a good list of new compounds highly active against Gram-positive bacteria, but only very few active against multi-resistant Gram-negatives in the pipeline.
The number of chaperone molecules will likely increase in the next few years: studies with high-throughput screenings represent an efficient way of identifying new compounds for new diseases (Urban et al, 2008; Zheng et al, 2007).
Various new compounds and materials for photo-catalysis have been synthesized in the past few decades [5 13].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com