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The data suggested that vaccine escape mutants have derived from only few mutations at several antigenic sites.
This study showed that in South Asian regions, most antigenic variations of the FMDV serotype Asia1 come from very few mutations at several antigenic sites.
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We then (iii) generated a consensus repeat for each CRISPR locus exploiting the fact that repeats within a CRISPR locus are almost completely identical with some loci that carry few mutations, preferably at the start and end (see Supplementary Figure S3, Supplementary material).
SNAP at least was able to observe some signal: very few mutations with impact on structure were predicted at scores corresponding to predictions of strong effect upon function.
This could explain why so few mutations are seen in the genome at large.
Young species have relatively few mutations.
A few mutations had beneficial effects, making the individuals who had them more resistant to disease or better at doing monkey or mousy things.
A few mutations are beneficial, and the viruses that inherit those good mutations can swiftly dominate a viral population.
Over millions of years, an essential piece of DNA will gather few mutations compared with less important ones.
Mutations in SCN1A are associated with a spectrum of epilepsy syndromes [14]; a few mutations result in FHM [15].
This makes intuitive sense; large populations will produce more mutations but fix fewer of them while small populations will produce few mutations but fix more of them.
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