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While agreeing with much of Charlie Beckett's piece (We can make the leap into the digital future together, 26 March), a cursory glimpse at the comments from the Guardian's Open Weekend reveals few inputs from readers north of the Trent.

The lateral dorsal thalamic nucleus, however, receives very few inputs from the mammillary bodies (Vann et al., 2007), and for this reason will not be considered further in this review.

However, we found that dopamine neurons projecting to the posterior striatum were outliers, receiving relatively few inputs from the ventral striatum and instead receiving more inputs from the globus pallidus, subthalamic nucleus, and zona incerta.

As a result, our findings most closely match those reports using retrograde tracers that emphasize how the hippocampal prefrontal inputs arise from the prosubiculum and subiculum (Rosene and Van Hoesen 1977; Carmichael and Price 1995), with relatively few inputs from CA1.

Similar(55)

TS-projecting dopamine neurons received far fewer inputs from the nucleus accumbens, whereas TS-projecting neurons received uniquely higher numbers of inputs from the GP, STh, and ZI.

In the posterior midbrain, all populations received inputs from the dorsal raphe, but lHb-projecting dopamine neurons received fewer inputs from nearby areas.

However, we found that TS-projecting dopamine neurons did not show a similar concentration of inputs: these neurons received many fewer inputs from anterior regions and ventromedial regions.

In addition, lHb-projecting dopamine neurons received fewer inputs from posterior midbrain regions such as the periaqueductal grey and gigantocellular reticular nuclei.

As we discussed above, the most prominent inputs to the 'canonical' dopamine neurons are from the nucleus accumbens, a part of the ventral striatum, though TS-projecting dopamine neurons received far fewer inputs from the nucleus accumbens.

Combining glutamate uncaging with whole-cell recordings and biocytin filling, we revealed a novel cellular organization of LII/III: (1) "Lower LII/III" pyramidal cells receive a very strong excitatory input from lemniscal LIV and much fewer inputs from paralemniscal LVa.

In summary, our findings reveal an overall asymmetry in V1 and V2b in inputs, with flexor-related motor pools receiving proportionately fewer inputs from V2b INs and more from V1 INs, while V2b INs exhibit a bias toward extensor-related motor pools.

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