When prenatal rats were exposed on postnatal days 1 and 2 (total gestation is 21 days) and underwent the same testing regime as the GD13 rats, Levin et al. (2006) found fewer impairments to neurobehavioral function, with hypoactivity being the only significant effect observed.
These compensatory mechanisms, which are most likely controlled by a negative feedback system that keeps overall neuronal activity at physiological levels, could explain why some mouse models show remarkably few functional impairments and symptoms even with large plaque loads in the cortex.
From the clinical viewpoint, an effective antioxidant treatment could pay off for human tipplers: According to past studies, alcoholics--particularly elderly ones--in rehabilitation programs are more successful at kicking the habit if they have fewer cognitive impairments.
Encouragingly, when genetic techniques were used to reduce Gpr52 synthesis in a fruit fly model of Huntington's disease, the treated flies showed fewer movement impairments than flies that had not been treated.
In rodent models of FASD, pregnant females given nutrients high in antioxidant properties (e.g., vitamin C, vitamin E, omega-3 fatty acids) during the time they also are given alcohol, give birth to offspring with reduced oxidative stress and cell loss, and fewer behavioral impairments (Brocardo et al. 2011; Patten et al. 2013 a ).
Whereas it is commonly accepted that caring for an older person with dementia is more stressful than caring for a dependent relative without cognitive impairment, few studies have specifically addressed this issue.
Different profile of side effects (especially no neuropsychologic impairment, few allergic reactions).
A neuropsychological examination showed few alterations, with impairment of verbal memory, attention and ability to plan (WAIS: 64, Verbal: 69, Performance: 63).
The extent of DEX function indicated that while most patients displayed few signs of impairment of this function, there was a minority who did so (figure 1).
Although many studies have investigated depression or QOL of older adults with visual impairment, few have looked at the association between these two concepts for this population.
