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While disordered to ordered rearrangements are relatively common, the ability of proteins to switch from one ordered fold to a completely different fold is generally regarded as rare, and few fold switches have been characterized.
First, why the rate of molecular evolution is relatively constant across species and time, and second, why levels of allozyme diversity vary by no more than a few fold across almost all species [1], [2], [3].
Regarding the constitutive lac repressor, we argued that to get a close to linear induction profile and a low basal expression of the target gene in mycobacteria, we needed a few fold higher expression of Lac repressor in mycobacteria as compared to that present in wild type E. coli.
While our calculated IC50 values for CAS after 24 hours are a few fold higher than other cell-based assays (e.g., luciferase) performed at 48 72 hrs, these population-based readouts will also be highly dependent on the actual concentrations of R1881 used for the competition [28].
Adding HOPS increases the amount of trans-SNARE interaction only a few fold, while it increases the rate of fusion much more dramatically (> 100-fold).
It has been reported that the former usually contribute more (a few fold higher than the later) to the total thiols contents [ 54].
Similar(48)
Next to the structures are rudimentary dining areas, often consisting of no more than a plastic tarp and a few fold-up chairs and tables.
The interior is a sleek composition of gray chrome curves (overhead luggage racks, deeper and wider than their predecessors) and red-and-cream details (the seating and a few fold-out benches).
They grew up in a small house in blue-collar Middletown, Rhode Island, where bedtime was "a never-ending revolving search to nab one of a few fold-up cots or a bunk bed that was open," and breakfast could involve fighting "for the last glass of powdered milk," Flynn writes, in his book, "Field of Fight".
A few folding tables down was Tommi Bryan from Tronox factory, which is based in Henderson, just south of Las Vegas.
IT WAS A SPECTACULAR LATE-MAY AFTERNOON IN SOUTHERN ITALY,but the streets of Laviano — a gloriously situated hamlet ranged across a few folds in the mountains of the Campania region — were deserted.
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