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After Phase 1, where the Cortex+Nucleus group had acquired few CRs, learning in Phase 2 was at a rate comparable to that of the Control group in Phase 1 (see Figure 3).
In our study, even those children who gave few CRs during delay conditioning showed consolidation and generalisation at the start of trace conditioning indicating normal cerebellar function.
Evidence provided by Coffin et al. (2005) was particularly compelling, since in their study children with dyslexia gave very few CRs, whereas in the Nicolson et al., study the deficit was in CR timing.
The development of autologous stem cell rescue allowed safe escalation of the dose of melphalan to 200 mg m−2 and resulted in even higher remission rates, with CR being reported in approximately 50% of patients compared to the very few CRs that were traditionally seen with standard dose treatments such as oral melphalan.
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In the forensic context this is particularly relevant for the few CR haplotypes that are shared more commonly within a population.
The large amplitude of individual events raises the intriguing possibility that this can be accomplished by very few CR cells, potentially even a single one.
This suggests that only few CR cells are required to control the activity of postsynaptic interneurons, and explains the powerful disynaptic GABAergic input observed onto pyramidal cells following CR cell optogenetic stimulation (Quattrocolo and Maccaferri 2014).
Compared with the controls, the exposed workers had higher levels of both at all of the time points (except for a few Cr-EBC levels at T2) (p < 0.01).
However, the majority was located in the middle portion of layer 1 and only a few CR cells were located near the pial surface or at the layer 1/layer 2/3 border (Figs. 4, 5a1, a2).
The Cortex+Nucleus group expressed significantly fewer CRs during Phase 1 compared to the Control, Nucleus Only, and Off-Target groups (Dunn's post hoc test, all comparisons P<0.05).
Compared to the Nucleus group, both the Cortex+Nucleus and the Control groups expressed significantly fewer CRs, with the Cortex+Nucleus group also at significantly lower levels than the Off-Target group (Dunn's test, P<0.05).
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